Resistive magneto-hydrodynamic (MHD) simulations are used to evaluate the influence of three-dimensional inhomogeneities on x-ray power production in wire array Z-pinches. In particular, we concentrate on simulations of wire array Z-pinch experiments on the MAGPIE generator at Imperial College. An initial temperature perturbation is used to stimulate variations in wire core ablation rates that result in a highly non-uniform final implosion. Results indicate that x-ray power production is governed by the symmetry of the implosion surface and by the rate at which current can transfer to the axis through a three-dimensional debris field that trails behind the main implosion. The peak power is ultimately limited by the growth of MHD instabilities in the stagnated pinch. The individual contributions of the implosion kinetic energy, compression of the stagnated pinch, ohmic heating and MHD instabilities to the radiation yield are quantified. The onset of m = 1 instabilities is found to provide an efficient mechanism for dissipation of the magnetic energy surrounding the stagnated pinch. The formation of a helical plasma column not only allows the magnetic field to do work in driving an expansion of the helix but also enhances the ohmic heating by elongating the path of the current through the pinch. The effect of these energy sources combined is to increase the radiation yield to typically 3½ times the kinetic energy of the implosion. Simulations of arrays with different wire numbers, wire material and with nested arrays are used to examine the mechanisms that influence the peak soft x-ray power. In the simulations, peak power can be increased by: increasing the number of wires (which improves the implosion symmetry), by increasing the atomic number of the material (which increases the compressibility of the plasma) and by using a nested inner array (which brings the mass and the current to the axis more efficiently than a single array).