AbstractTPE-RX is a large-sized reversed-field pinch machine newly constructed at the Electrotechnical Laboratory. In this paper the design concepts, procedures to determine the machine size and the flux swing to drive the plasma current, and the prediction of the global confinement properties of the TPE-RX are reported. From these considerations, major and minor radii (R, a) are decided to be R/a=1.7175/0.45 m, respectively. It is estimated that the flux swing of the iron core of more than 3.9 Wb is necessary to drive 1 MA of plasma current, Ip, which is the given constraint of the machine. Energy confinement time in the range of 3–18 ms is predicted to be attained at Ip=1 MA depending on the models and assumptions.