We describe how a new framework for coupling a full-particle-in-cell (PIC) algorithm with a reduced PIC algorithm has been implemented into the OSIRIS code. We show that OSIRIS, with this new hybrid-PIC algorithm, can efficiently and accurately model high energy density scenarios such as ion acceleration in laser–solid interactions and fast ignition of fusion targets. We model, for the first time, the full-density range of a fast ignition target in a fully self-consistent hybrid-PIC simulation, illustrating the possibility of stopping the laser generated electron flux at the core region with relatively high efficiencies. Computational speedups greater than 1000 times are demonstrated, opening the way for full-scale multi-dimensional modeling of high energy density scenarios and the guiding of future experiments.