Impact-driven shock waves, thermonuclear plasma and neutron yield were investigated. The results of 2D numerical simulations and Gekko/HIPER laser experiments on the collision of a laser-accelerated disk-projectile with a massive target, both containing (CD)n-material, are discussed. A two-temperature model of the non-equilibrium plasma created by impact-driven shock waves due to the collision of a laser-accelerated planar projectile with a massive target was developed and used for analysis of the numerical and experimental results. The model defines the characteristics of shock waves and plasmas (including their lifetime) as well as neutron yields in both the colliding objects as functions of velocity, density and mass of the projectile–impactor just before collision. The neutron yield generated during the period of laser-driven acceleration of the impactor was also determined.Two effects were discovered that exert a substantial influence on the plasma parameters and neutron yield. The first of them relates to the formation of the pre-impact state of the impactor. It decreases the projectile density due to thermal expansion of its matter through a free boundary during the period of laser-driven acceleration. The other relates to the formation of impact-produced plasma. Predominant heating of the ion component of plasma leads to the existence of a non-equilibrium two-temperature plasma during the period of electron–ion relaxation.