Owing to the recent progress of `profile controls' utilizing the freedom of profiles of plasma parameters, various types of combined (advanced) H-modes have been obtained; PEP H-mode, high- H-mode, high- H-mode, high- H-mode, reversed shear H-mode, CH-mode, VH-mode, etc. These combined H-modes with high potential for confinement and stability are characterized by improved transport in the core region in addition to the edge or deep inward penetration of the edge confinement pedestal. Such additional improvements seem to be related to flow shear, magnetic shear, safety factor, density profile or . The improved confinement region can propagate from the core to the edge or from the edge to the core, or appear almost simultaneously over the whole radius. However, there are some critical issues to be solved concerning reactor conditions, that is, under electron heating at high edge density with small impurity accumulation in the steady-state. Most of the NB heated combined H-modes have been obtained with ion heating, where ion thermal diffusivity and particle diffusivity can be reduced to the neoclassical level. However electron thermal diffusivity has so far not been clearly reduced except in the H-mode and in the VH-mode. Therefore, improvement of electron transport is one of the main issues. The second issue is that some improved modes are accompanied by strong density peaking which may result in large impurity accumulation. The third issue is the difficulty in achieving the improved modes at a high edge density with the high particle recycling essential for a dense and cold divertor. The fourth issue is the stability at high in the steady state. It is not certain that pressure and current profiles including the bootstrap current can be sustained stably. The requirement of ELMs for heat and particle exhaust is also an important issue in stability design as concerns the extent of the second regime access for the high-n ballooning mode.