In the JET tokamak, ICRF driven fusion reactivity has been determined using measurements of 16.6 MeV γ-ray emission from d[3He, γ]5Li reactions during central RF heating in the (3He)d minority regime. Up to 1 MJ of fast minority ions in the plasma has been produced with the application of up to 15 MW of RF power. The maximum rate produced by d[3He, p]4He fusion reactions has been estimated as 2 × 10l6 s−1 (equivalent to 60 kW of fusion power in charged particle products). The reactivity increased strongly with coupled RF heating power (proportional to (PRF)5/3), with some evidence of a weakening of the dependence leading to a saturation in the energy gain Q at the highest coupled RF power levels (PRF > 8−12 MW). The experimentally measured anisotropic fast ion energies and fusion reaction rates have been simulated using a radially dependent Stix model for a wide variety of discharges. Analysis of the radial profile of fusion reactivity shows that when the RF power density is maximized on the magnetic axis of the discharge, the fusion reactivity is peaked away from the axis. This effect is caused by the minority ions near the centre of the discharge being driven to energies beyond the maximum in the fusion cross-section.