Focal spot effects on the generation of proton beams are investigated by a high-intensity high-contrast laser irradiating on solid foil in target normal sheath acceleration experiments. Different spot size, transverse shape, and intensity of the laser are obtained by appropriately using deformable mirrors and parabolic mirrors. Experiments show that the maximum proton energy is mainly determined by the laser intensity if the focal spot size is not seriously changed. Compared with the previous experimental results, the optimum foil thickness do is scaled by the laser intensity I as do ~ I0.33. The corresponding theoretical estimation is carried out as do ~ I0.25 for ultra-high intensity laser systems with similar contrast. MULTI and particle-in-cell simulations are used to interpret the experimental results.