The neutron yield produced by D(d,n)3He fusion reactions in plasma skin layer has been derived from interaction of a high-intensity picosecond laser with thin TiD2 films. Multiple ionization of Ti atoms is considered at the leading edge of the laser pulse. Heating of free electrons is produced by inverse induced bremsstrahlung at the elastic scattering of electrons on multicharged Ti atomic ions. The electron temperature is derived. It is of the order of 10 keV at the peak laser intensity of 5×1018 W cm−2. The neutron yield is equal to ∼104 per laser pulse. This is in qualitative agreement with the known experimental data.