The paper is devoted to a detailed analysis of hot non-relativistic D6 Li and DD plasmas. Non-isothermic processes in hot DD plasmas and their effect on energy release, loss, etc. are studied. The nonconventional D6Li plasma is investigated as a promising thermonuclear fuel. The presence of lithium in the deuterium plasma is shown to be an active factor increasing the energy release, as compared with the catalytic DD reaction, and to change the energy generation mechanism.