In the Tandem Mirror Experiment (TMX), the central-cell losses provide the warm unconfined plasma necessary to stabilize the drift-cyclotron loss-cone instability in the end cells. This places a theoretical limit on central-cell confinement, which is expressed as a limit on the end-cell to central-cell density ratio. As this density ratio increases in a TMX experiment, large increases of end-cell ion-cyclotron-frequency plasma fluctuations are observed. These fluctuations cause the central-cell confinement to decrease, in agreement with a theoretical model.