Recent progress in the RF low activation structural materials R&D road map towards DEMO via the FBR tests (BOR-60, BN-600, BN-800) and the TBM tests in ITER is overviewed. The properties of the RAFMS RUSFER-EK-181 (Fe–12Cr–2W–Ta–V–B–C) and the V–4Ti–4Cr alloys are presented. The next important steps include further studies on the influence of high dose and high-temperature irradiation on the properties of base structural materials and joints. Activation, transmutation and radiation damage of the materials in BN-600 and DEMO-RF (Kurchatov Institute project) neutron spectra are calculated. The results of the application of the internal friction (ultrasonic) non-destructive method to research the DBTT are in good agreement with the results of the destructive impact method. The important influence of boron on the heat resistance of materials and the He concentration level under irradiation are calculated. The new special regimes of the heat treatments of the alloys are suggested to widen the temperature windows of the applications. The results of the BOR-60 examinations of RUSFER-EK-181 (irradiation temperature 320–340 °C and doses up to 15 dpa) are presented. The BN-600 projects for the high dose and high-temperature irradiation tests of manufactured alloys are presented.