Local gyrokinetic simulations are used to model turbulent transport for the first time in a representative high-performance plasma discharge projected for the new JT-60SA tokamak. The discharge features a double-null separatrix, 41 MW of combined neutral beam heating and electron cyclotron heating, and a high predicted ratio of the normalized plasma kinetic to magnetic pressure β. When considering input parameters computed from reduced transport models, gyrokinetic simulations predict a turbulent heat flux well below the injected 41 MW. Increasing the background gradients, on the other hand, can trigger a non-zonal transition (NZT), causing heat fluxes to no longer saturate. Furthermore, when considering fast ions in the simulations, a high-frequency mode is destabilized that substantially impacts the turbulence. The NZT is avoided by reducing the electron pressure by 10% below its nominal value, and the fast-ion resonance is removed by reducing the fast-ion temperature. The thus-obtained simulation features broadband frequency spectra and density and temperature fluctuation levels –2%, –6% that should be measurable with fluctuation diagnostics planned for JT-60SA. The temperature profile is fixed by the critical main-ion temperature gradient as a consequence of the high stiffness; heat fluxes increase by a factor of ten when increasing the main ion temperature gradient by 17%. Despite large gradients, it is demonstrated that, due to the large β, retaining compressional magnetic field fluctuations and in particular, the contribution of the pressure gradient in the drifts, is crucial to achieving non-zero heat fluxes.