This article introduces an updated focus of plasma nanoscience after a dozen years of successful international research efforts. The concept of plasma-nano-interface involves two fundamental options: plasmas in contact with nanoscale features and plasmas which have nanoscale dimensions on their own. Non-equilibrium and transient features pertinent to the both cases are discussed in view of the recent progress in the field. Plasma-like phenomena in nanometer-sized materials, the third dimension of plasma nanoscience, also benefit from the insights based on fundamentals of plasma physics. Opportunities for future science discoveries, cross-disciplinary collaborations and translational research and development are highlighted.