DIII-D experimental results are reported to demonstrate the potential of physics-model-based safety factor profile control for robust and reproducible sustainment of advanced scenarios. In the absence of feedback control, variability in wall conditions and plasma impurities, as well as drifts due to external disturbances, can limit the reproducibility of discharges with simple pre-programmed scenario trajectories. The control architecture utilized is a feedforward + feedback scheme where the feedforward commands are computed off-line and the feedback commands are computed on-line. In this work, a first-principles-driven (FPD), physics-based model of the q profile and normalized beta () dynamics is first embedded into a numerical optimization algorithm to design feedforward actuator trajectories that steer the plasma through the tokamak operating space to reach a desired stationary target state that is characterized by the achieved q profile and . Good agreement between experimental results and simulations demonstrates the accuracy of the models employed for physics-model-based control design. Second, a feedback algorithm for q profile control is designed following an FPD approach, and the ability of the controller to achieve and maintain a target q profile evolution is tested in DIII-D high confinement (H-mode) experiments. The controller is shown to be able to effectively control the q profile when is relatively close to the target, indicating the need for integrated q profile and control to further enhance the ability to achieve robust scenario execution. The ability of an integrated q profile + feedback controller to track a desired target is demonstrated through simulation.