Multi-scale interactions have been observed recently in the HL-2A core NBI plasmas, including the synchronous coupling between kink mode and tearing mode, nonlinear couplings of TAE/BAE and TM near surface, AITG/KBM/BAE and kink mode near surface, and between kink mode and high-frequency turbulence. Experimental results suggest that several couplings can exist simultaneously, Alfvenic fluctuations have an important contribution to the high-frequency turbulence spectra, and the couplings reveal the electromagnetic character. Multi-scale interactions via the nonlinear modulation process maybe enhance plasma transport and trigger sawtooth-crash onset.