This study presents the first comprehensive computation of nuclear heat deposition in the ITER Vacuum Vessel (VV) using the E-lite model, a complete 360° reference neutronics model of the ITER tokamak. Accurate characterization of nuclear heat in the ITER VV is critical for maintaining safe operation. Significant updates to E-lite were made, focusing on two key areas: improved blanket representation and inclusion of previously missing components. Our findings indicate a total nuclear heat deposition of 18.87 MW in the VV, marking a 4.4% increase from previous estimates. Conservative maximum power deposition during a DT 500 MW inductive pulse is estimated at 20.8 ± 2.3 MW (1σ). Detailed 3D maps of nuclear heat deposition were generated, revealing energy distribution across different VV regions and identifying areas with volumetric power deposition above 0.61 W cm−3, a threshold to prevent mechanical stress. Detailed 3D maps of nuclear heat deposition provide critical input for the thermo-hydraulic analyses necessary for ITER design verification.