Fusion development will require materials capable of withstanding extensive harsh bombardment by energetic neutrons and plasma. The plasma-based gas dynamic trap neutron source concept is capable of testing and qualifying materials and fusion blanket sub-modules for eventual deployment in fusion energy systems. In this paper we describe the suitability of this source to assess thermal fatigue in fusion blanket components caused by the small normal variability of neutron flux inherent in fusion energy concepts. A second part of the paper considers the requirements for a fusion–fission hybrid suitable for producing fissile fuel. Both solid and molten salt fuel from blanket designs are described which emphasize non-proliferation and passive safety.