The mechanism of internal transport barrier (ITB) collapse in the reversed magnetic shear configuration is investigated using a global ion temperature gradient (ITG) driven drift wave turbulence code. A heating source and a toroidal momentum source are introduced to follow the self-consistent evolution of the ion temperature and flow profiles. A scenario of transport barrier collapse driven by a meso-scale mode excited in the barrier region is suggested. The importance of the quasi-linear effect due to profile modification as well as three-wave coupling is clearly shown by means of energy transfer analysis. The effect of the toroidal flow shear (TFS) profile on the dynamics of ITB evolution is investigated. It is found that the decorrelation between meso-scale modes and ITG driven modes due to the TFS can prevent global relaxation.