Natural basis functions (NBF), also known as natural pixels in the literature, have been applied in tomographic reconstructions of soft x-ray (SXR) measurements in the JET (Joint European Torus) tokamak. The results are compared with those obtained with local basis functions (LBF), and those obtained with a conventional constrained-optimization tomography method. Truncated singular value decomposition is used as the inversion method. Reconstructions without a prioriinformation, such as the NBF reconstructions, are, as can be expected, less good than reconstructions in which a prioriinformation is used, as in the conventional method, but the reconstructions are shown to be reliable by means of phantom simulations. Reconstructions with the same number of LBFs as NBFs without a prioriinformation are comparable to NBF reconstructions, although the latter seem to be somewhat better. No significant changes in results, apart from smaller reconstruction errors, are obtained if the measuring system has more regular or complete coverage than the JET SXR system. The various tomography methods are used to assess whether a newly observed in-out asymmetry in the SXR emission during the injection of nickel into an RF-heated plasma, with the peak on the inboard side, is real. A possible explanation for the asymmetry in emissivity is an increased nickel density on the inboard side as a result of an RF-induced increase of the hydrogen-minority density on the outboard side.